Preheat Oven: Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper or a silicone mat to prevent sticking.
Combine Ingredients: In a large mixing bowl, combine ground sausage, shredded cheddar cheese, biscuit mix, garlic powder, onion powder, and paprika (if using). Mix thoroughly using your hands or a sturdy spoon until all ingredients are evenly combined.
Check Mixture Consistency: If the mixture feels too dry and crumbly, add 1–2 tablespoons of milk and mix again until the mixture holds together when shaped.
Shape the Balls: Scoop about 1–1.5 tablespoons of the mixture and roll it into a ball. Place the sausage balls onto the prepared baking sheet, leaving about 1 inch of space between each.
Bake: Bake in the preheated oven for 20–25 minutes, or until the sausage balls are golden brown and cooked through (internal temperature should reach 160°F/71°C).
Cool and Serve: Let the sausage balls cool on the baking sheet for 2–3 minutes before transferring them to a cooling rack. Serve warm as an appetizer or snack.